ABRAHAM, SUNNY,BHAGWAT, SHRIPAD S.,CAMPBELL, BRIAN T.,CHAO, QI,FARAONI, RAFFAELLA,HOLLADAY, MARK W.,LAI, ANDILIY G.,ROWBOTTOM, MARTIN W.,SETTI, EDUARDO,SPRANKLE, KELLY G.
申请号：
ES09722418
公开号：
ES2547406T3
申请日:
2009.03.17
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound having the formula VA or VB: ** Formula ** or a pharmaceutically acceptable salt, solvate or hydrate thereof, where r is 1 or 2； X is O or S； n is 1 to 4； R3 is O； m is 0 to 2； R3 is lower alkyl or halo. R4 and R5 are each independently hydrogen or methyl； R10 is independently selected from halo, haloalkyl, alkyl, cycloalkyl, aryl, heterocyclyl, heteroaryl and where the alkyl group is optionally substituted with 1 or 2 groups selected from halo, cyano, and cycloalkyl and where the cycloalkyl, aryl and heteroaryl is optionally substituted with 1 or 2 groups selected from halo, cyano, alkyl and haloalkyl； and R1 is selected as follows: i) each R1 is absent or independently selected from the group consisting of halo, nitro, amino, alkyl, cycloalkylalkyl, heterocyclylalkyl, aralkyl, heteroaryl, heteroaralkyl, cycloalkylcarbonylamino, -R6OR7, -R6OR9OR7 and -R6OR9N (R7) 2； or ii) the two adjacent groups R1 form an alkylenedioxy group； each R6 is independently a direct bond, an alkylene chain or an alkenylene chain； each R7 is independently selected from (i) or (ii) below: (i) each R7 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl and heteroaralkyl, or (Ii) two R7 groups, which together with the N atom to which they are attached form a heterocyclyl or heteroaryl； each R9 is independently an alkylene chain or an alkenylene chain； where the R1, R6, R7 and R9 groups are optionally substituted with one, two or three Q1 groups, wherein each Q1 is independently haloalkyl, alkyl, -RUOX, -RUOUOX, -RUC (J) ORX, - RUS (O) 2RW, -RUN (RX) S (O) 2RW or - RUN (RX), RUS (O) 2RW, where ku is a direct bond or alkylene, Rx is hydrogen or alkyl； Rw is alkyl and J is O, S or NRx, or in which formulas VA and VB correspond to formulas XVII and XIX as defined in claims 6 and 7, respectively.Un compuesto que tiene la fórmula VA o VB:**Fórmula** o una sal farmacéuticament
