THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人:
BACCHETTA, MATTHEW,CHICOTKA, SCOTT,FUNG, KENMOND,GUENTHART, BRANDON,O'NEILL, JOHN,VUNJAK-NOVAKOVIC, GORDANA,ONEILL, JOHN
申请号：
CA3030789
公开号：
CA3030789A1
申请日:
2017.07.13
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Described are systems, methods, and devices relating to normothermic extracorporeal support of an organ, tissue, or bioengineered graft comprising cross-circulation (XC) perfusion for prolonged periods (days to weeks) via an XC perfusion circuit in connection with an extracorporeal host (e.g., animal, patient, organ transplant recipient) are disclosed. The XC perfusion circuit comprises auto-regulation of blood flow based on the trans-organ blood pressure difference between arterial and venous pressure. Recipient support enabled 36 h of normothermic perfusion that maintained healthy lungs with no significant changes in physiologic parameters and allowed for the recovery of injured lungs. Extended support enabled multiscale therapeutic interventions in all extracorporeal lungs. Lungs exceeded transplantation criteria.
