UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人:
CHAVES FONTES, Paulo, A.,VAN DER PLAATS, Arjan
申请号：
USUS2016/051122
公开号：
WO2017/044861A1
申请日:
2016.09.09
申请国别(地区):
WO
年份:
2017
代理人:
摘要：
Disclosed herein is a device for machine perfusion of an organ that includes a chamber including an organ support platform for supporting an organ and a perfusion circuit for providing an oxygenated perfusion fluid to the organ and carrying oxygen-depleted perfusion fluid away from the organ. The organ support platform includes perforations for fluid drainage. In some examples, the organ support platform is substantially horizontal. The device also includes a pump for circulating the perfusion fluid through the perfusion circuit, an oxygenating device in the perfusion circuit to oxygenate the perfusion fluid, and a temperature regulator for controlling the temperature of the perfusion fluid in the perfusion circuit. The device in some examples also includes a vascular perfusion cannula through which the perfusion fluid can flow to an organ placed on the organ support platform. Also disclosed are methods of perfusing an organ utilizing the machine perfusion devices.Linvention concerne un dispositif destiné à la perfusion machine dun organe qui comprend une chambre comprenant une plate-forme de support dorgane permettant de supporter un organe et un circuit de perfusion servant à fournir un fluide de perfusion oxygéné à lorgane et demporter un fluide de perfusion appauvri en oxygène à distance de lorgane. La plate-forme de support dorgane comprend des perforations destiné au drainage de fluide. Dans certains exemples, la plate-forme de support dorgane est sensiblement horizontale. Le dispositif comprend également une pompe permettant de faire circuler le fluide de perfusion à travers le circuit de perfusion, un dispositif doxygénation dans le circuit de perfusion pour oxygéner le fluide de perfusion, et un régulateur de température permettant de commander la température du fluide de perfusion dans le circuit de perfusion. Le dispositif, dans certains exemples de linvention, comprend également une canule de perfusion vasculaire au moyen de laquelle le fluide de perfusi
