ANTAGONISTES DE PAN-HER ET PROCEDES D'UTILISATION

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专利权人:

INC.;MOLECULAR LOGIX

发明人:

PIENKOS, PHILIP, T.,MONTICELLO, DANIEL, J.

申请号：

EP05763234

公开号：

EP1838730A4

申请日:

2005.06.30

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

The present invention features human epidermal receptor (HER) antagonists. These antagonists are polypeptide variants of ligands of HER. The HER ligand polypeptide variants of the invention possess Pan-HER antagonistic properties and can inhibit at least one HER-mediated biological activity of one or more HER subtypes, such as inhibition of the receptor's kinase activation activity and subsequently, cell proliferation. Such polypeptide variants, and nucleic acids encoding these polypeptide variants can be used therapeutically in situations in which inhibition of HER activity is indicated.

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