William WINSTON,Daniel HICKLIN,Vinay BHASKAR,Luke EVNIN,Patrick BAEUERLE,Jose Andres SALMERON GARCIA,Heather BRODKIN
申请号：
US16438156
公开号：
US20200040052A1
申请日:
2019.06.11
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The disclosure features fusion proteins that are conditionally active variants of IL-2. In one aspect, the full-length polypeptides of the invention have reduced or minimal cytokine-receptor activating activity even though they contain a functional cytokine polypeptide. Upon activation, e.g., by cleavage of a linker that joins a blocking moiety, e.g., a steric blocking polypeptide, in sequence to the active cytokine, the cytokine can bind its receptor and effect signaling.
