GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
发明人:
Lewis Lee Brayshaw,Michael Menteith Hann,Christopher Herring,Carlos Martinez Fleites,Markus Alexander Queisser
申请号：
US16879896
公开号：
US20200283538A1
申请日:
2020.05.21
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention relates to a method of controlling the level of a polypeptide sequence comprising administering a polypeptide sequence fused to a ubiquitin targeting protein which comprises a minimal degron structural motif. In particular, the polypeptide sequence comprises a chimeric antigen receptor therefore the present invention is useful in methods of cell and gene therapy where the activity of the chimeric antigen receptor needs to be controlled.
