Kevin Williams,Paul Rayhorn,Ellen A. Garber,R. Blake Pepinsky
申请号：
US10164282
公开号：
US08410061B2
申请日:
2002.06.05
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Variants of hedgehog protein that contain N-terminal modifications are described that can block hedgehog function thus allowing these variants to serve as functional antagonists. These peptides have a primary amino acid sequence lacking the ability to elicit a hedgehog-dependent response in C3H 10T1/2 cells but having the ability to bind to the hedgehog receptor, patched-1. Methods for producing such functional antagonists and methods of using the functional antagonists are also described.
