COMPOSES AROMATIQUES D'ARYLSULFONYLMETHYLE OU D'ARYLSULFONAMIDE SUBSTITUES PERMETTANT DE TRAITER DES TROUBLES REPONDANT A UNE MODULATIONDU RECE PTEUR D3 DE LA DOPAMINE
DRESCHER, KARLA,HAUPT, ANDREAS,UNGER, LILIANE,TURNER, SEAN C.,BRAJE, WILFRIED,GRANDEL, ROLAND,HENRY, CHRISTOPHE
申请号：
CA2583779
公开号：
CA2583779C
申请日:
2005.10.14
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention relates to aromatic compounds of the formula (I),wherein Ar is phenyl or an aromatic 5- or 6-membered C-bound heteroaromaticradical, wherein Ar may carry 1 radical Ra and wherein Ar may also carry 1 or2 radicals Rb； X is N or CH； Y is O, S, -CH=N-, -CH=CH- or -N=CH-； A is CH2i Oor S； E is CR6R7 or NR 3； R1 is C1-C4-alkyl, C3-C4-cycloalkyl, C3-C4-cycloalkylmethyl, C3-C4-alkenyl, fluorinated C1-C4-~alkyl, fluorinated C3-C4-cycloalkyl, fluorinated C3-C4-cycloalkylmethyl, fluorinated C3-C4~-alkenyl,formyl or C,-C3-alkylcarbonyl； R1a is H, C2-C4-alkyl, C3-C4-cycloalkyl, C3-C4-alkenyl, fluorinated C1-C4-alkyl, fluorinated C3-C4 -cycloalkyl, or R1a and R2together are (CH2)n with n being 2 or 3, or R1 a and R2a together are (CH2)nwith n being 2 or 3； R2 and R2a are independently of each other H, CH3, CH2F,CHF2 or CF3； R3 is H or C1-C4-alkyl； R6, R7 independently of each other areselected from H, C1-C2-alkyl and fluorinated C1-C2-alkyl； and thephysiologically tolerated acid addition salts thereof. The invention alsorelates to the use of a compound of the formula I or a pharmaceuticallyacceptable salt thereof for preparing a pharmaceutical composition for thetreatment of a medical disorder susceptible to treatment with a dopamine D3receptor ligand.
