Joshua Engstrom;Keith P. Johnston;Robert O. Williams, III
发明人:
Keith P. Johnston,Joshua Engstrom,Robert O. Williams, III
申请号：
US12665386
公开号：
US08968786B2
申请日:
2008.06.20
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents； spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm−1 area/volume to, e.g., increase protein stability； and contacting the droplet with a freezing surface that has a temperature differential of at least 30° C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm−1.
