The present disclosure relates to azabicyclo octane derivatives, preparation processes and pharmaceutical compositions containing them. Specifically, the present disclosure relates to novel azabicyclo octane derivatives presented by formula (I), the uses for treatment especially for dopamine, norepinephrine and serotonin reuptake inhibitors, in which each substitute group of general formula (I) is as defined in the specification.本發明涉及氮雜雙環辛烷類衍生物、其製備方法及其在醫藥上的應用,特別是一種通式(I)所示的新的氮雜雙環辛烷類衍生物、其製備方法及含有該衍生物的藥物組合物以及其作為治療劑特別是作為多巴胺、去甲腎上腺素和五羥色胺再吸收抑制劑的用途。