The invention provides methods for predicting the efficacy of anti-TNF and anti-IL17 combination therapies in the treatment of a subject suffering from inflammatory disease by determining the level CXCL1 and/or CXCL5 markers in a sample derived from the subject.本發明中提供之方法,其係以評量來自於個體之試樣的CXCL1及/或CXCL5標記之量,預測抗-TNF與抗-IL-17組合療法在治療患發炎性疾病之個體的藥效。