The invention relates to an in vitro method for predicting metastasis in a subject diagnosed with breast cancer and treated with a taxane, to an in vitro method for selecting breast cancer patients having a risk of developing metastasis after treatment with a taxane and to an in vitro method for designing personalized therapy for a subject suffering breast cancer and being treated with a taxane based on determining the level of GRP94 and/or FN14. The invention also relates to a composition comprising a taxane and a GRP94 inhibitor and/or an FN14 inhibitor and to the use thereof in the treatment of brain metastasis.
