Composed of small molecules that inhibit Cdk8 and cdk19, excluding cortistatina and other farmceutica； formulation； a method for treating a Mammal that has a disease related to Cdk1 as E. Alzheimer dementias, amyloidosis, and a method for a patient quimioproteger Q EU suffers from Breast or Ovarian Cancer, among others.
ROBINSON, IGOR, B,PORTER, DONALD, C,WENTLAND, MARK, P.
申请号：
CL2014002062
公开号：
CL2014002062A1
申请日:
2014.08.01
申请国别(地区):
CL
年份:
2015
代理人:
摘要：
The Invention relates to the compounds and Methods for inhibiting the Cyclin Dependent Kinase Inhibitor (CDKI) Pathway. More particularly, The Invention relates to compounds and Methods for inhibiting the CDKI pathway for Studies of and intervention in Senescence CDKI - related and other related diseases.The Invention Provides New compounds having improved solubility and / or potency, and Methods for their use. In various aspects, The Invention relates to the treatment of cancer. The Invention provides Meth<；p>；La invenció；n se relaciona con compuestos inhibidores de quinasa dependiente de ciclina (CDKI) y su uso para el tratamiento del cá；ncer. La invenció；n provee compuestos con solubilidad y/o potencia mejorada.<；/p>；
