Anne VERHAGEN,Sabine PESTEL,Thomas WEIMER,Marco HOFMANN,Huy HUYNH,Eugene MARASKOVSKY
申请号：
US16624365
公开号：
US20200197495A1
申请日:
2018.06.22
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to a recombinant polypeptide comprising a truncated von Willebrand Factor (VWF) capable of binding to blood coagulation Factor VIII (FVIII) for use in reducing the immunogenicity of Factor VIII (FVIII) wherein said recombinant polypeptide and a blood coagulation Factor VIII (FVIII) protein are co-administered to a subject suffering from a 10 blood coagulation disorder. The invention further relates to pharmaceutical compositions and kits for said use.
