The present invention relates to a triamcinolone acetonide ophthalmic preparation and a preparation method thereof. The main components of the ophthalmic preparation are: 0.05% to 0.5% of triamcinolone acetonide, 0.1% to 0.9% of sodium chloride, 1.0% to 5.0% of hydroxypropyl methyl cellulose, 0.05% to 0.2% of polysorbate 80, an appropriate amount of buffer solution, and sterile purified water. Sterilized triamcinolone acetonide and polysorbate 80 are mixed evenly, and an appropriate amount of sterile purified water is added to produce a suspension. Sodium chloride, ethylenediamine tetraacetic acid calcium sodium, benzalkonium bromide, acetic acid, sodium acetate, and boric acid are introduced to an appropriate amount of sterile purified water, and then dissolved to form a solution. The formed suspension and the formed solution are mixed evenly and sterilized at 100℃. Sterilized solution is then mixed evenly with a hydroxypropyl methyl cellulose solution. Sterilized purified water is then added till sterilized purified water accounts for 90% of the liquid volume. Finally sterilized NaOH or HCl solution is used to adjust the pH value to be 5 to 7. The ophthalmic preparation is formed after sterilized purified water is used to dilute and to fix the volume of the solution. The ophthalmic preparation has the advantages of having an appropriate degree of viscosity, a high degree of bioavailability, and low irritation to eyes.Linvention concerne une préparation ophthalmique dacétonide de triamcinolone et son procédé de préparation. Les constituants principaux de cette préparation ophthalmique sont : 0,05% à 0,5% dacétonide de triamcinolone, 0,1% à 0,9% de chlorure de sodium chloride, 1,0% à 5,0% dhydroxypropyl-méthyle cellulose, 0,05% à 0,2% de polysorbate 80, une quantité appropriée de solution tampon, et de leau purifiée stérile. Lacétonide de triamcinolone et le polysorbate 80 stérilisés sont mélangés de manière homogène, et une quantité appropriée deau purifié stérile
