A pharmaceutical composition comprising a cultured primary pre-adipocyte, wherein the pre-adipocyte stably maintains a foreign gene that encodes a protein that is secreted outside the cell, and where the gene has been inserted into a vector. retroviral and has been transferred to the cell by the retroviral vector, where the protein is lecithin cholesterol acyltransferase (LCAT).Una composición farmacéutica que comprende un pre-adipocito primario cultivado, en donde el pre-adipocito mantiene de forma estable un gen extraño que codifica una proteína que es secretada en el exterior de la célula, y en donde el gen ha sido insertado en un vector retroviral y ha sido transferido a la célula por el vector retroviral, en donde la proteína es lecitina colesterol aciltransferasa (LCAT).
