作為RET激酶抑制劑之經取代吡唑基[4,3-C]吡啶化合物农业专利-农业学术服务平台

发明人:: BLAKE, JAMES F.,布莱克　詹姆士　Ｆ,布萊克　詹姆士　Ｆ,DAI, DONGHUA,戴　东华,戴　東華,HAAS, JULIA,哈斯　茱莉亚,哈斯　茱莉亞,JIANG, YUTONG,江　育童,江　育童,KAHN, DEAN,可翰　狄恩,可翰　狄恩,KOLAKOWSKI, GABRIELLE R.,科拉柯斯基　盖比尔　Ｒ,科拉柯斯基　蓋比爾　Ｒ,MCFADDIN, ELIZABETH

摘要：: Provided herein are compounds of the Formula I:and tautomers and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2and R3have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.本文中提供式I化合物，及其互變異構體及醫藥學上可接受之鹽及溶劑合物，其中R1、R2及R3具有說明書中所給出之含義，其為RET激酶之抑制劑且適用於治療及預防可用RET激酶抑制劑治療之疾病，包括RET相關疾病及病症。