作為ＴＲＫ激酶抑制劑之經取代吡唑并〔１，５－ａ〕嘧啶化合物农业专利-农业学术服务平台

发明人:: ALLEN, SHELLEY,艾伦　雪莉,艾倫　雪莉,ANDREWS, STEVEN W.,安德鲁斯　史蒂文Ｗ,安德魯斯　史蒂文Ｗ,CONDROSKI, KEVIN R.,康得罗斯基　凯文Ｒ,康得羅斯基　凱文Ｒ,HAAS, JULIA,哈斯　茱莉亚,哈斯　茱莉亞,HUANG, LILY,黄莉莉,黃莉莉,JIANG, YUTONG,江育童,KERCHER, TIMOTHY,克莱契尔　提摩西,艾伦雪莉,艾倫雪莉,安德鲁斯史蒂文W,安德魯斯史蒂文W,康得罗斯基凯文R,康得羅斯基凱文R,哈斯茱莉亚,哈斯茱莉亞,克莱契尔提摩西

摘要：: Compounds of FormulaI:and salts thereof in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.一種具有結構式I之化合物：及其鹽類，其中R1、R2、R3、R4、X、Y以及n具有該說明給定的意義，為Trk激酶之抑制劑以及在治療疾病上為有效用的，該疾病可以Trk激酶抑制劑治療，像是疼痛、癌症、炎症、神經退化疾病以及特定的感染疾病。