作為TAM及MET激酶抑制劑的吡唑并[3,4-b]吡啶化合物农业专利-农业学术服务平台

发明人:: HINKLIN, RONALD JAY,新可林　罗纳德　杰,新可林　羅納德　傑,ALLEN, SHELLEY,艾伦　雪莉,艾倫　雪莉,BARBOUR, PATRICK,巴柏　派翠克,巴柏　派翠克,COOK, ADAM,库克　亚当,庫克　亞當,DAHLKE, JOSHUA,戴克　约书亚,戴克　約書亞,GAUDINO, JOHN,高狄诺　约翰,高狄諾　約翰,LAIRD, ELLEN,赖尔德　伊连恩,賴

摘要：: Provided herein are compounds of the FormulaI:and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein R1, R2, R9, X1and G are as defined herein, which are inhibitors of one or more TAM kinases and/or c-Met kinase, and are useful in the treatment and prevention of diseases which can be treated with a TAM kinase inhibitor and/or a c-Met kinase inhibitor.本文提供式I化合物：以及其立體異構體、互變異構體及醫藥學上可接受的鹽，其中R1、R2、R9、X1以及G如本文所定義；式I化合物以及其立體異構體、互變異構體以及醫藥學上可接受的鹽是一種或多種TAM激酶及/或c-Met激酶的抑制劑，並且適用於治療及預防能夠用TAM激酶抑制劑及/或c-Met激酶抑制劑治療的疾病。