用作CBP和/或EP300抑制劑的4，5，6，7-四氫-1H-吡唑並[4，3-C]吡啶-3-胺化合物

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专利权人:

Genentech, Inc.;Constellation Pharmaceuticals, Inc.;Constellation Pharmaceuticals, Inc.;星座製藥股份有限公司

发明人:

ROMERO, F. Anthony,MAGNUSON, Steven,PASTOR, Richard,TSUI, Vickie Hsiao-Wei,MURRAY, Jeremy,CRAWFORD, Terry,ALBRECHT, Brian, K.,COTE, Alexandre,TAYLOR, Alexander, M.,LAI, Kwong Wah,CHEN, Kevin, X.,BRONN

申请号：

HK18108300

公开号：

HK1248695A1

申请日:

2018.06.28

申请国别(地区):

HK

年份:

2018

代理人:

摘要：

The present invention relates to compounds of formula (I) or formula (II):and to salts thereof, wherein R<；sup>；1<；/sup>；-R<；sup>；4<；/sup>；of formula (I) and R<；sup>；1<；/sup>；-R<；sup>；3<；/sup>；of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

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中国工程科技知识中心

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http://www.ckcest.cn/home/