Anti-cancer antibodies with reduced complement fixation

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专利权人:

发明人:

Stephen D. Gillies

申请号：

US15483698

公开号：

US10017579B2

申请日:

2017.04.10

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The invention provides modified antibodies directed against GD2 that have diminished complement fixation relative to antibody-dependent, cell-mediated cytotoxicity, which is maintained. The modified antibodies of the invention may be used in the treatment of tumors such as neuroblastoma, glioblastoma, melanoma, small-cell lung carcinoma, B-cell lymphoma, renal carcinoma, retinoblastoma, and other cancers of neuroectodermal origin.

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