MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG
发明人:
GILLIES, STEPHEN D.
申请号：
CA2553883
公开号：
CA2553883C
申请日:
2005.01.18
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention provides modified antibodies directed against GD2 that havediminished complement fixation relative to antibody-dependent, cell-mediatedcytotoxicity, which is maintained. The modified antibodies of the inventionmay be used in the treatment of tumors such as neuroblastoma, glioblastoma,melanoma, small-cell lung carcinoma, B-cell lymphoma, renal carcinoma,retinoblastoma, and other cancers of neuroectodermal origin.
