METHODS OF TREATMENT WITH NATURAL KILLER CELLS MATCHED FOR KILLER IMMUNOGLOBULIN RECEPTOR TYPE

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专利权人:

BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人:

REZVANI, Katy,SHPALL, Elizabeth,LIU, Enli

申请号：

WO2016US36024

公开号：

WO2016197108(A1)

申请日:

2016.06.06

申请国别(地区):

世界知识产权组织国际局

年份:

2016

代理人:

摘要：

The present invention concerns methods of treating a disease such as leukemia in a subject by administering natural killer (NK) cells. In particular aspects, HLA-C1-licensed KIR2DL2/3 and KIR2DS2 NK cells are administered to a subject with an HLA-C genotype either homozygous or heterozygous for the C1 allele, or HLA-C2 licensed cells are administered to a subject with an HLA-C genotype homozygous for the C2 allele. In further aspects, the NK cells are genetically modified to express a chimeric antigen receptor and interleukin 15.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/