PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY;YOSHINDO INC.;TOKYO INSTITUTE OF TECHNOLOGY
发明人:
WADA, TADASHI,TAKEDA, KEI,HANDA, HIROSHI
申请号：
CA2842580
公开号：
CA2842580A1
申请日:
2012.07.17
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Provided is an artificial gene expression inhibition method which can be designed more readily compared with conventional methods (an RNAi method, a ribozyme method, an antisense method), and in which the effect thereof can be confirmed readily. Provided are: a method for inhibiting the translation reaction of a target gene, which comprises cleaving out a part of a poly(A) chain and/or a 3'-terminal sequence of target mRNA； a kit for inhibiting a translation reaction, which comprises a reagent capable of cleaving out a part of a poly(A) chain and/or a 3'-terminal sequence of target mRNA； a cell into which a reagent capable of cleaving out a part of a poly(A) chain and/or a 3'-terminal sequence of target mRNA is introduced so as to inhibit the translation reaction of a target gene； and a non-human living organism into which a reagent capable of cleaving out a part of a poly(A) chain and/or a 3'-terminal sequence of target mRNA is introduced so as to inhibit the translation reaction of a target gene.
