Provided is an artificial gene expression inhibition method which can be designed more readily compared with conventional methods (an RNAi method a ribozyme method an antisense method) and in which the effect thereof can be confirmed readily. Provided are: a method for inhibiting the translation reaction of a target gene which comprises cleaving out a part of a poly(A) chain and/or a 3 terminal sequence of target mRNA a kit for inhibiting a translation reaction which comprises a reagent capable of cleaving out a part of a poly(A) chain and/or a 3 terminal sequence of target mRNA a cell into which a reagent capable of cleaving out a part of a poly(A) chain and/or a 3 terminal sequence of target mRNA is introduced so as to inhibit the translation reaction of a target gene and a non human living organism into which a reagent capable of cleaving out a part of a poly(A) chain and/or a 3 terminal sequence of target mRNA is introduced so as to inhibit the translation reaction of a target gene.
