Piperidine- and piperazine-1-carboxylic acid amide derivatives and related compounds as modulators of fatty acid amide hydrolase (faah) for the treatment of anxiety, pain and other conditions
APODACA, RICHARD,BREITENBUCHER, J. GUY,PATTABIRAMAN, KANAKA,SEIERSTAD, MARK,XIAO, WEI
申请号：
ES05855824
公开号：
ES2542021T3
申请日:
2005.12.29
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
Compound of Formula (I): ** Formula ** in which: - Z is -N- or>； CH； - R 1 is -H or -C 1-4 alkyl； - Ar1 is 2-thiazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, each unsubstituted or substituted on a carbon ring member with one or two Ra moieties； wherein each Ra residue is independently selected from the group consisting of -C1-4 alkyl, -C2-4 alkenyl, -OH, -C1-4 alkyl, halo, -CF3, -OCF3, -SCF3, -SH, - S (O) 0-2 C1-4alkyl, -OSO2 C1-4alkyl, -CO2C1-4alkyl, -CO2H, -C1-4alkyl, -N (Rb) Rc, -SO2NRbRc, -NRbSO2Rc, -C (>； = O) NRbRc, -NO2 and -CN, in which Rb and Rc are each independently -H or -C 1-4 alkyl； and - Ar2 is: (a) unsubstituted 1-naphthyl； or a phenanthrenyl, pyrenyl, fluorenyl, 2-naphthyl or N-Rd-9H-carbazolyl moiety, wherein Rd is selected from the group consisting of -H, -C 1-4 alkyl and phenyl, each of said unsubstituted moieties or substituted with one, two or three substituents Re, in which each substituent Re is independently selected from the group consisting of -C 1-4 alkyl, -C 2-4 alkenyl, -OH, -C 1-4 alkyl, halo, -CF 3 , -OCF3, -SCF3, - SH, -S (O) 0-2 C1-4alkyl, -OSO2 C1-4alkyl, -CO2C1-4alkyl, -CO2H, -C1-4alkyl, -N (Rb) Rc, -SO2NRbRc, -NRbSO2Rc, -C (>； = O) NRbRc, -NO2 and -CN, in which Rb and Rc are as defined above； (b) phenyl condensed on two adjacent carbon atoms of the ring with a group selected from the group consisting of - (CH2) 3-5- which has 0 or 1 double bonds, -OCH2CH2O- and -OCF2O- to form a structure of condensed ring； or phenyl substituted on adjacent carbon atoms of the ring with -OCH2O- to form 4-benzo [1,3] dioxolyl； each phenyl moiety not further substituted or substituted with one, two or three substituents Re as defined above； (c) Ar6, in which Ar6 is a 6-membered monocyclic heteroaryl having carbon as a fixation point, with one or two nitrogen heteroatoms, unsubstituted or substituted with one, two or three R substituents as defined above. ； (d) a 9 or 10-membered fused bicyclic heteroary
