Phenylamide derivatives of 4- (benzyl) -piperazine-1-carboxylic acid and related compounds as modulators of fatty acid amide hydrolase (FAAH) for the treatment of anxiety, pain and other conditions
A compound of Formula (I): ** Formula ** in which: * Z is -N- or>； CH； * R1 is -H or -C 1-4 alkyl； * Ar1 is 2-thiazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, or phenyl, each unsubstituted or substituted on a carbon ring member with one or two Ra remains； wherein each Ra residue is independently selected from the group consisting of -C1-4 alkyl, -C2-4 alkenyl, -OH, -C1-4 alkyl, halo, -CF3, -OCF3, -SCF3, -SH, - S (O) 0-2 C1-4alkyl, -OSO2 C1-4alkyl, -CO2C1-4alkyl, -CO2H, -C1-4alkyl, -N (Rb) Rc, -SO2NRbRc, -NRbSO2Rc, -C (>； = O) NRbRc, -NO2 and -CN, in which Rb and Rc are each independently -H or -C 1-4 alkyl； and - Ar2 is: phenyl fused to two adjacent carbon atoms of the ring with a group selected from the group consisting of - (CH2) 3-5- which has 0 or 1 double bonds, - (CH2) 2-3O-, - OCH2CH2O- and -OCF2O- to form a condensed ring structure； or phenyl substituted on adjacent carbon atoms of the ring with -OCH2O- (to form 4-benzo [1,3] dioxolyl)； each phenyl moiety not further substituted or substituted with one, two or three substituents Re in which each substituent Re is independently selected from the group consisting of -C 1-4 alkyl, -C 2-4 alkenyl, -OH, -C 1-4 alkyl, halo, -CF3, -OCF3, -SCF3, -SH, -S (O) 0-2 C1-4alkyl, -OSO2C1-4alkyl, -CO2C1-4alkyl, -CO2H, -C1-4alkyl, -N ( Rb) Rc, -SO2NRbRc, -NRbSO2Rc, -C (>； = O) NRbRc, -NO2 and -CN, in which Rb and Rc are as defined above； or a pharmaceutically acceptable salt of such compound.Un compuesto de Fórmula (I):**Fórmula** en el que: * Z es -N- o >；CH； * R1 es -H o -alquilo C1-4； * Ar1 es 2-tiazolilo, 2-piridilo, 3-piridilo, 4-piridilo, 2-pirimidinilo, 4-pirimidinilo, 5-pirimidinilo, o fenilo, cada uno no sustituido o sustituido en un miembro del anillo carbonado con uno o dos restos Ra； en el que cada resto Ra está seleccionado independientemente del grupo que consiste en -alquilo C1-4, -alquenilo C2-4, -OH, -Oalquilo C1-4, halo, -CF3, -OCF3, -SCF3, -SH, -S(O)0-2alquilo
