An efficacious antibacterial and anti-inflammatory oral composition is provided having an active ingredient combination comprising one or more active compounds from an extract of magnolia and an extract of hops. Preferably, the active compounds from magnolia extract comprise honokiol and magnolol, and the active compounds from hops extract comprise hexahydrogenated beta acids. The oral composition can be in the form of a mouth rinse or dentifrice, including toothpaste, gels, powders, confectionaries, lozenges, animal products, and the like. Methods of making and using the oral composition are also provided.提供一種有效之抗菌及消炎之口腔組成物,其具有一種活性成分組合物,包含一或多種來自木蘭萃取物和蛇麻子萃取物之活性化合物。較佳地,來自木蘭萃取物之活性化合物包含和朴酚及厚朴酚,來自蛇麻子萃取物之化合物包含六氫化之β酸。口腔組成物可為漱口水或潔齒劑形式,包括牙膏、凝膠、粉末、糖果、錠劑、動物性產品及類似物。亦提供製造及使用口腔組成物之方法。