The present invention provides a brake control system and method of an auto-wheelchair. The auto-wheelchair includes an electronic gradienter, a brake sensor, a brake device, and a brake controller. The brake control system includes a slope angle detection module, a brake detection module, a brake adjustment module, and a brake alarm module. The system and method can detect and analyze the current driving status of the auto-wheelchair in real time, and control the brake device to adjust the brake of the auto-wheelchair using the use the brake controller according to the detected a driving status, so as to avoiding the auto-wheelchair to turn over when the auto-wheelchair drives on the slope road or the user improperly brakes the auto-wheelchair.一種電動輪椅之煞車控制系統及方法,該電動輪椅包括電子水平儀、煞車感測器、煞車裝置及煞車控制器。所述之煞車控制系統包括傾斜角度偵測模組、煞車偵測模組、煞車調整模組及煞車警示模組。本發明所述之煞車控制系統及方法,能夠藉由電子水平儀針對使用者乘坐電動輪椅之狀況進行即時偵測、確認,隨時與煞車感測器所測得之煞車狀況進行分析,自動透過煞車控制器對煞車裝置進行控制作業,可有效避免使用者因操作不當或緊急煞車等狀況而引起輪椅重心偏移,發生翻覆等意外。1...電動輪椅10...煞車控制系統101...傾斜角度偵測模組102...煞車偵測模組103...煞車調整模組104...煞車警示模組11...電子水平儀12...煞車感測器13...煞車裝置14...煞車控制器15...儲存器16...微處理器