An apparatus for fixing a pipe of a vehicle may include: a clip adapted that a fixation hole and an assembly hole are formed at a first end thereof and a mounting portion is formed in a hollow cylindrical shape at a second end thereof bent and extended from the first end to insert the pipe into the hollow; a first rubber member being fixed to a vehicle body by a bush on a state of being inserted into the fixation hole of the clip; a second rubber member being inserted into the hollow of the mounting portion on a state of surrounding the pipe; and an insulation member adapted that a first side thereof is inserted into the assembly hole and a second side thereof formed in a bellows shape is supported to the vehicle body.