CHAPARRO RIGGERS, JAVIER FERNANDO,VAN BLARCOM, THOMAS JOHN,BOLDAJIPOUR, BIJAN ANDRE
申请号：
CA3057265
公开号：
CA3057265A1
申请日:
2018.04.18
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention provides compositions and methods that downregulate major histocompatibility class I molecule cell surface expression, and uses of such compositions and methods for improving the functional activities of isolated T cells (e.g., gene-modified antigen-specific T cells, such as chimeric antigen receptor T (CAR-T) cells). In particular, the present invention provides methods and compositions for bolstering the therapeutic efficacy of CAR-T cells.
