Allogene Therapeutics Inc.;BOLDAJIPOUR Bijan Andre;VAN BLARCOM Thomas John;CHAPARRO RIGGERS Javier Fernando
发明人:
CHAPARRO RIGGERS Javier Fernando,VAN BLARCOM Thomas John,BOLDAJIPOUR Bijan Andre
申请号：
IL26933419
公开号：
IL269334D0
申请日:
2019.09.13
申请国别(地区):
IL
年份:
2019
代理人:
摘要：
The present invention provides compositions and methods that downregulate major histocompatibility class I molecule cell surface expression, and uses of such compositions and methods for improving the functional activities of isolated T cells (e.g., gene-modified antigen-specific T cells, such as chimeric antigen receptor T (CAR-T) cells). In particular, the present invention provides methods and compositions for bolstering the therapeutic efficacy of CAR-T cells.
