Disclosed is a natural orifice translumenal minimally invasive surgical apparatus comprising a control box assembly sequentially connected with a hose assembly, a serpentine structure and a tip assembly at a middle position at a distal end of the control box assembly. Axes of the hose assembly and the serpentine structure are coincident with an axis of the tip assembly. The control box assembly is configured to position and replace a minimally invasive surgical instrument, support the surgical tool when being operated, and perform a minimally invasive surgery. The hose assembly is configured to provide passageways for the minimally invasive surgical instrument and a transmission wire and to output motions and loads. The tip assembly is configured to support the minimally invasive surgical instrument when being operated and enable the surgical instrument to have an enlarged motion space range. The apparatus has advantages including convenient operation, accurate actions and good real-time performance, achieves the basic goal of minimally invasive surgery, expands the flexibility of the movement, increases the operating space of the surgical instruments, and enables the minimally invasive surgery to be carried out in a handheld manner.
