GUZZO, PETER,SURMAN, MATTHEW DAVID,HENDERSON, ALAN JOHN,JIANG, MAY XIAOWU,HADDEN, MARK,GRABOWSKI, JAMES,USYATINSKY, ALEXANDER
申请号：
ES12163813
公开号：
ES2523580T3
申请日:
2009.01.09
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of formula I: wherein R 1 is H optionally substituted alkyl； R2, R3, R4 are each independently selected from H, -O-alkyl, -S-alkyl, alkyl, halo, -CF3, and -CN； G is -CR12R13-NR5- or -NR5-CR12R13； R5 is H, optionally substituted alkyl, optionally substituted heterocycle, -C (>； = O) -R6, -C (>； = O) -O-R7, or -C (>； = O) -NR19R20； R6 and R7 are each optionally substituted alkyl or optionally substituted heterocycle； R8, R9, R10, R11, R12, R13, R19 and R20 are each independently selected from H optionally substituted alkyl； R14 and R15 are each independently H or halogen； Y is CH or N； L is -CH2-O-, -CH2CH2-, -CH>； = CH- or a link； and B is aryl or heteroaryl or cycloalkyl； with the proviso that, when L is a direct bond, B cannot be unsubstituted heteroaryl or fluorinated monosubstituted heteroaryl； wherein (a) "alkyl" means a linear, branched or cyclic hydrocarbon, or combinations thereof, having 1 to 20 carbon atoms； (b) "cycloalkyl" means a cyclic hydrocarbon having 3 to 8 carbon atoms； (c) "alkoxy" means a straight, branched or cyclic configuration of C1 to C8, or combinations thereof, attached to the original structure through an oxygen, including methylenedioxy and ethylenedioxy； (d) "aryl" means an aromatic ring, including monocyclic aromatic rings of 5 or 6 members, bicyclic aromatic rings of 9 or 10 members and tricyclic aromatic rings of 13 or 14 members； (e) "heteroaryl" means a heteroaromatic ring containing one, two or three heteroatoms selected from O, N or S, including monocyclic aromatic rings of 5 or 6 members, bicyclic aromatic rings of 9 or 10 members and tricyclic aromatic rings of 13 or 14 members； and (f) "substituted" means that up to three H atoms are replaced with alkyl, halogen, haloalkyl, hydroxy, lower alkoxy, carboxy, carboalkoxy, carboxamido, cyano, carbonyl, nitro, amino, alkylamino, dialkylamino, mercapto, alkylthio, sulfoxide, sulfone, acylamino, amidino, phenyl, bexyl, heteroaryl, phenoxy, benxyloxy or heteroaryloxy
