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ИНГИБИТОРЫ ГИДРОЛАЗЫ АМИДОВ ЖИРНЫХ КИСЛОТ ДЛЯ ЛЕЧЕНИЯ БОЛИ
专利权人:
АЛЛЕРГАН; ИНК. (US)
发明人:
ВУДВАРД Дэвид Ф. (US),МАРТОС Джоуз Л. (GB),КАРЛИНГ Уильям Р. (GB),ДЖОНС Эндрю Д. (GB),ВАНГ Дженни В. (US)
申请号:
RU2013156028/15
公开号:
RU2013156028A
申请日:
2012.05.23
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A method for treating a patient suffering from pain by administering an inhibitory amount of fatty acid amide compound represented by the formula: wherein R is H R is a radical selected from the group consisting of H, a hydrocarbon radical and substituted hydrocarbon radical R is a radical, selected from the group consisting of H, a hydrocarbon radical and substituted hydrocarbon radical X is CHCH, (CH) or O (CH), wherein n is 0 or an integer from 1 to 4 and W represents O, S or NR, wherein R c is selected from the group consisting of H and alkila.2. A method according to claim 1, characterized in that W represents O.3. A method according to claim 1, characterized in that R is a radical selected from the group consisting of H, alkyl, haloalkyl and arila.4. A method according to claim 2, characterized in that R c is selected from the group consisting of ethyl, methyl, 2-methylethyl, phenyl, trifluoromethyl, and 2,2,2-triftoretila.5. A method according to claim 1, characterized in that R c is selected from the group consisting of H, alkyl, alkenyl, and arila.6. A method according to claim 4, characterized in that R c is selected from the group consisting of N-alkyl and N-cycloalkyl-alkila.7. A method according to claim 5, characterized in that R is (CH) CHR, wherein n is an integer from 4 to 9, a is H or tsikloalkil.8. A method according to claim 6, characterized in that R c is selected from the group consisting of: cyclohexyl-n-alkyl radikalov.9. A method according to claim 7, characterized in that R is cyclohexyl-n-butil.10. A method according to claim 1, characterized in that X is ethyl or etenil.11. A method according to claim 1, characterized in that said compound is selected from the group consisting of (E) -3R- [2R - [[3- [4 - [[(4-cyclohexyl1. Способ лечения пациента, страдающего от боли, путем введения ингибирующего амид жирной кислоты количества соединения, представленного формулой:где R1 представляет собой HR2 представляет собой радикал, выбранный из гру
来源网站:
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