REN MICHAEL DR. KOENIGS,MELANIE DR. REICH,STEFAN DR. SCHUNK
申请号：
ARP160103076
公开号：
AR106295A1
申请日:
2016.10.07
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
This refers to tetrahidropiranilsulfonas replaced with pirazolilo as blockers of voltage-gated calcium channels.Pharmaceutical compositions containing these Compounds, and these compounds for use in the prophylaxis and / or treatment of Pain and other diseases and / or conditions.Claim 1: a compound of General formula (1),Where r u00b9 is selected from the group consisting of H, alkyl or c u2081 u208b u2086； R u00b2 is selected from the group consisting r u00b3 represents H or alkyl c u2081 u208b u2086； l '- r u00b3 u1d43,Where l 'is a link or ch u2082 and r u00b3 u1d43 is selected from the group consisting c u2081 u208b u2086 substituted alkyl, cycloalkyl or c u2083 u208b u2086 heterociclilo 3 to 7 members,Where the alkyl substituted c u2081 u208b u2086 is replaced with one or two substituents selected from the group consisting of independently och u2083, Oh, u2082ch u2083 (S = o) n ( u2082 ch u2083), C (= o) nh u2082,C (= o) NH (ch u2083) and C (= o) n (ch u2083) u2082； where the c u2083 u208b u2086 cycloalkyl and said heterociclilo 3 to 7 members are not substitute or substituted with one or two substituents selected independently of the GHe is och u2083, = o or s (= o) u2082ch u2083, nh u2082, NH (ch u2083), N ( u2082 ch u2083), C (= o) - C (= o) nh u2082,C (= o) NH (ch u2083) and C (= o) n ( u2082 ch u2083)； and where the heterociclilo 3 to 7 members contain one or two hetero Atoms or groups of hetero Atoms selected from the group consisting or independently, NH,N (ch u2083), S (= o) and S (= o) - r u2075 u2082； r u2074 represents L, where l is a Link, ch u2082, C (ch u2083) u2082, o or s (= o) u2082 and r u2075 is selected from the group consisting c u2081 u208b u2086 rent,C u2083 u208b u2086 cycloalkyl or heterociclilo 3 to 7 members, where the heterociclilo 3 to 7 members is characterized because it contains an Atom or group of heteroatoms selected from o, NH,N (ch u2083), S (= o) and S (= o) u2082； where this is not c u2081 u208b u2086 alkyl substi
