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WATER-SOLUBLE TAXANE DERIVATIVES AND USES THEREOF
专利权人:
Jiangsu Nhwaluokang Pharmceutical Research and Development Co. Ltd.
发明人:
LI, Qingeng,WANG, Tao,CHEN, Gang,WANG, Yuanzhong,MAO, Wei,ZENG, Lingguo,WU, Tong,CHEN, Dahai
申请号:
EP15749707
公开号:
EP3109242A4
申请日:
2015.02.16
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
The present invention discloses a class of water soluble taxane derivatives, a method for treating tumor using the same, use thereof as anti-tumor drugs and use thereof in the preparation of anti-tumor drugs. The water soluble taxane derivatives have the general formula (I-1), (I-2) or (I-3): wherein, R 1 is H or methyl R 2 is H, methyl or acetyl R 3 is phenyl or OC(CH 3 ) 3 X is H, C 1-6 alkyl or F Y is F or C 1-6 alkyl substituted with one or more F n is 1, 2, 3, 4, 5 or 6 W is NR 4 R 5 ·A or R 4 and R 5 are each independently H, C 1-6 alkyl optionally substituted with phenyl, or C 3-6 cycloalkyl m is 0, 1, 2 or 3 and A is a pharmaceutically acceptable acid.
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