CORTEZ, ALEX,LI, YONGKAI,WU, TOM YAO-HSIANG,YUE, KATHY,ZHANG, XIAOYUE,SINGH, MANMOHAN,SKIBINSKI, DAVID
申请号：
PE2012000285
公开号：
PE20121156A1
申请日:
2010.09.01
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
For a formula (I) derivative,Where R1 is C1-C4, C (R5) 2O h, l1r5, l2r5, l2r5, etc.； L1 is C (o) or O； L2 is C1-C6, alquenileno C2-C6, etc.； R2 is h or C1-C4； R3 is l3r5, l1r5, ol3r5, etc.； R5 is p (o) (O H) 2. ]] - nafi-3 - (2 - (2 - (1,3) - Nafi]]]]] - nafi-1 - (- (2 - (3,3-fluoro-3-phosphate-proposxi) - etoxi-2-methyl-styrene) - benzo - [F] [1, [7] - naftiridin-8-il) - propane,There are others These compounds are modulators of toll (TLS) receptor and can be used to treat asthma, ulcerative colitis, Crohn's disease, bronchitis, Soria's disease, etc.REFERIDA A UN DERIVADO DE NAFTIRIDILO DE FORMULA (I), DONDE R1 ES ALQUILO C1-C4, C(R5)2OH, L1R5, L2R5, ENTRE OTROS； L1 ES C(O) U O； L2 ES ALQUILENO C1-C6, ALQUENILENO C2-C6, ENTRE OTROS； R2 ES H O ALQUILO C1-C4； R3 ES L3R5, L1R5, OL3R5, ENTRE OTROS； R5 ES P(O)(OH)2. SON COMPUESTOS PREFERIDOS: ACIDO 4-(4-(2-(5-AMINO-8-METIL-BENZO-[f][1,7]-NAFTIRIDIN-2-IL)-ETIL)-3-METIL-FENOXI)-1,1-DIFLUORO-BUTIL-FOSFONICO, ACIDO 3-(5-AMINO-2-(4-(4,4-DIFLUORO-4-FOSFONO-BUTOXI)-2-METIL-FENETIL)-BENZO-[f][1,7]-NAFTIRIDIN-8-IL)-PROPANOICO, 3-(5-AMINO-2-(4-(2-(3,3-DIFLUORO-3-FOSFONO-PROPOXI)-ETOXI-2-METIL-FENETIL)-BENZO-[f][1,7]-NAFTIRIDIN-8-IL)-PROPANOICO, ENTRE OTROS. DICHOS COMPUESTOS SON MODULADORES DE LOS RECEPTORES TIPO TOLL (TLRs) Y SON UTILES EN EL TRATAMIENTO DE ASMA, COLITIS ULCERATIVA, ENFERMEDAD DE CROHN, BRONQUITIS, SORIASIS, ENTRE OTRAS
