PARK, Chun Eung (KR),ПАРК Чун Еунг (KR),JANG, Young Koo (KR),ДЗАНГ Янг Коо (KR),SHIN, Yong Je (KR),ШИН Йонг Дзе (KR),KIM, Ji Yeon (KR),КИМ Дзи Йеон (KR),HAM, Seung Mo (KR),ХАМ Сеунг Мо (KR),KIM, Yong
申请号：
RU2017131514
公开号：
RU0002710556C2
申请日:
2016.02.25
申请国别(地区):
RU
年份:
2019
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to a compound of chemical formula (1) or a pharmaceutically acceptable salt thereof, in which X is CH or N； Z is O or S； R1 is phenyl, optionally substituted with one or more substitutes selected from halogen, hydroxy, C1-C5 alkyl, C1-C5 alkoxy, C1-C5 alkylthio, amino, di(C1-C5)alkylamino, cyano, formyl, halogen-C1-C5 alkyl, hydroxy-C1-C5 alkyl, C1-C5 alkoxy C1-C5 alkyl, carbamoyloxyC1-C5 alkyl, C1-C5 alkyl-C(O)O-C1-C5 alkyl, di(C1-C5)alkylamino-C1-C5 alkyl and 5-member heterocyclic1-C5 alkyl, where heterocycloalkyl has 1 heteroatom selected from N； or 9-member unsaturated heterocyclyl, having 2 heteroatoms selected from O, which is optionally substituted with one or more substitutes selected from halogen； 5–10 membered heteroaryl having 1 or 2 heteroatoms selected from N or S, which is optionally substituted with one or more substitutes selected from halogen, hydroxy, C1-C5 alkyl, C1-C5 alkoxy, halogenC1-C5 alkyl and di(C1-C5)alkylamino, and R2 is phenyl, optionally substituted with one or more substitutes selected from halogen, deuterium and hydroxy, or 6–10-member heteroaryl, having 1 or 2 heteroatoms selected from N, which is optionally substituted with one or more substitutes selected from halogen and C1-C5 alkyl. Invention also relates to a pharmaceutical composition for preventing or treating a disorder mediated by dysfunction of glutamate and a metabotropic glutamate receptor of subtype 5 (mGluR5).EFFECT: technical result is obtaining novel compounds of formula (1), having the properties of a positive allosteric modulator of metabotropic receptor glutamate subtype 5 (mGluR5).19 cl, 1 tbl, 199 exИзобретение относится к соединению химической формулы (1) или его фармацевтически приемлемой соли, в которой X представляет собой CH или N； Z представляет собой O или S； R1 представляет собой фенил, необязательно замещенный одним или более заместителями, выбранными из галогена, гидрокси, С1-С5 алкила, С1-С5 алкокси, С1-С5
