DELGADO, Mercedes (US),БЕННЕТТ Брайдон Л. (US),YOON, Won, Hyung (US),ЭЛЬСНЕР Ян (US),TIKHE, Jayashree (US),ЭРДМАН Пол (US),SATOH, Yoshitaka (US),ХИЛГРАФ Роберт (US),ROMANOW, William, J. (US),ЛЕБРЭН Ло
申请号：
RU2017121958
公开号：
RU0002697712C2
申请日:
2012.04.20
申请国别(地区):
RU
年份:
2019
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to use of diaminopyrimidine compound of formula I or IB, or its pharmaceutically acceptable salt, or its deuterated form. Invention also relates to versions of method of producing compound I. In compound of formula I, , (Ia), (IIa),R1 and R2 independently represent unsubstituted C1-8alkyl； C1-8alkyl substituted with one or more halogen atoms, hydroxy, C1-3alkoxy, C1-3alkoxyC1-3alkyl, halogen C1-3alkoxy or hydroxyC1-3alkyl； unsubstituted saturated 3–7-membered monocycloalkyl or 5–8-member bicycloalkyl； substituted saturated 3–7-member monocycloalkyl or 5–8-member bicycloalkyl, where substitutes are selected from halogen, C1-6 alkyl, hydroxy, oxo, C1-3alkoxy, C1-3alkoxyC1-3alkyl, halogen C1-3alkyl, halogen C1-3alkoxy, hydroxyC1-3alkyl, aminoC1-3alkyl, O-cyclopropyl, NH2, NH(C1-3) alkyl, N(C1-3alkyl)2, C(O)-C1-3alkyl, NHC(O)-C1-3alkyl, C(O)NH2, C(O)NHC1-3alkyl, C(O)N(C1-3alkyl)2, NHSO2(C1-3alkyl) and pyrrolidyl； unsubstituted C1-3alkyl-C3-6cycloalkyl； 4–6-member non-aromatic monocyclic heterocyclyl, optionally N-substituted with C1-3alkyl C(O) or optionally substituted C1-3alkyl, oxo or hydroxy, in which the heteroatoms are selected from 1 to 2 oxygen atoms or 1 nitrogen atom； or dioxaspirotecanil. In a compound of formula (IB) R3 and R4 independently represent unsubstituted C1-8alkyl； unsubstituted saturated 3–7-membered monocycloalkyl or 5–8-member bicycloalkyl； substituted saturated 3–7-member monocycloalkyl or 5–8-member bicycloalkyl, where substitutes are selected from halogen, C1-6alkyl, hydroxy, C1-3alkoxy, C1-3alkoxyC1-3alkyl, halogen C1-3alkyl, halogen C1-3alkoxy, hydroxyC1-3alkyl, O-cyclopropyl, NH(C1-3)alkyl, N(C1-3alkyl)2, C(O)-C1-3alkyl, NHC(O)-C1-3alkyl, C(O)NHC1-3alkyl and C(O)N(C1-3alkyl)2； unsubstituted C1-3alkyl-C3-6cycloalkyl； 4–6-member non-aromatic monocyclic heterocyclyl, in which heteroatoms are selected from 1–2 oxygen atoms or 1 nitrogen atom； or dioxaspirotecanil. Method of producing compound (I)
