Колесанова Екатерина Федоровна (RU),Егорова Елена Александровна (RU),Мишин Александр Александрович (RU),Пындык Надежда Вячеславовна (RU),Фарафонова Татьяна Евгеньевна (RU),Ельская Анна Валентиновна (U
申请号：
RU2013135511/10
公开号：
RU2013135511A
申请日:
2013.07.30
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A peptide derivative, to generate specific antibodies in the body interacting with 2 isoform translation elongation factor 1A humans and other mammals (assuming identity of amino acid sequences of these proteins), but do not interact with one isoform translation elongation factor 1A, of general formula IX-KSDPPQEAAQFTS -NH-CH (CHCHCOOH) -COY (X-lysyl-seryl-glutamyl-prolyl-prolyl-glutaminyl-glutamyl-alanyl-alanyl-glutaminyl-phenylalanyl-seryl-threonyl-glutamate or -glutamatamid) (I), or a pharmaceutically acceptable salt thereof, or a salt thereof vat where X - acetyl group or a hydrogen atom, Y-NH- or OH-group, and the remainder of the peptide derivative is a fragment of the amino acid sequence 2 isoform of human translation elongation factor 1A, comprising amino acid residues 330 № № 343.2. Method production in an animal monospecific antibodies reactive with isoform 2 translation elongation factor 1A humans and other mammals (assuming identity of amino acid sequences of these proteins), but not interacting with the isoform 1 of this factor, comprising administering to the animal an effective dose of conjugate peptide derivative of claim. 1 with a carrier protein in a composition with a publicly known adyuvantami.3. Use of the peptide derivative of claim 1 for affinity purification of monospecific antibodies reactive with 2 isoform translation elongation factor 1A humans and mammals, but not interacting with the isoform 1 of faktora.4. A method for determining isoform 2 translation elongation factors 1A humans and other mammals (provided that they frag1. Пептидное производное, для выработки в организме специфических антител, взаимодействующих с изоформой 2 фактора элонгации трансляции 1A человека и других млекопитающих (при условии идентичности аминокислотных последовательностей этих белков), но не взаимодействующих с изоформой 1 фактора элонгации трансляции 1A, общей формулы IX-KSDPPQEAAQFTS-NH-CH(CH2CH2COOH)-COY(Х-лизил-серил-глутамил-пролил-пролил-глутаминил-г
