ТОРРЕС Виктор Дж. (US),УНУТМАЗ Дерия (US),АЛОНСО Фрэнсис (US)
申请号：
RU2014101489/10
公开号：
RU2014101489A
申请日:
2012.06.19
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A method for preventing or treating a human immunodeficiency virus (HIV) infection in a subject, comprising: administering a composition comprising an isolated leukocidin E protein (LukE) or a polypeptide thereof and an isolated leukocidin D protein (LukD) or a polypeptide thereof, in an amount effective to prevent or treating HIV infection in a subject. 2. The method according to claim 1, which includes the use of a composition containing an isolated LukE protein containing the amino acid sequence of SEQ ID NO: 11 or an amino acid sequence having at least 70% sequence similarity with SEQ ID NO: 11.3. The method according to claim 1, characterized in that the composition contains an isolated LukE polypeptide, including amino acid residues 48-291 from SEQ ID NO: 11.4. The method according to claim 1, characterized in that the composition contains an isolated LukD protein comprising the amino acid sequence of SEQ ID NO: 22 or an amino acid sequence having at least 70% sequence similarity with SEQ ID NO: 22.5. The method according to claim 1, characterized in that the composition contains an isolated LukD polypeptide, including amino acid residues 46-307 from SEQ ID NO: 22.6. The method of claim 1, further comprising administering one or more antiviral or other agents suitable for treating HIV infection in combination with a formulation comprising an isolated LukE protein or polypeptide thereof and an isolated LukD protein or polypeptide thereof. The method of claim 6, wherein the antiviral agent is selected from the group consisting of a nucleoside reverse transcriptase inhibitor, a non-nucleoside reverse transcriptase inhibitor, and a protease inhibitor. The method according to claim 6, characterized in that the antiviral agent is selected from the group1. Способ профилактики или лечения инфекции вируса иммунодефицита человека (ВИЧ) у субъекта, включающий:введение состава, содержащего выделенный белок лейкоцидин Е (LukE) или его полипептид и выделенный белок лейко
