SON, JUN HO,손준호,PARK, TAE SOON,박태순,KIM, DONG HEE,김동희,HWANG, JU YOUNG,황주영,HWANG, EUN YOUNG,황은영,JUN, DONG HA,전동하,SIM, BO RAM,심보람
申请号：
KR1020110128534
公开号：
KR1020130062111A
申请日:
2011.12.02
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A Carthamus tinctorius seed extract is provided to remarkably suppress IL-1beta, IL-6, IL-8, TNF-alpha, NO, COX-2, and iNOS-2 generation, and to be used as an external use pharmaceutical composition or a cosmetic composition for preventing and treating inflammatory diseases.CONSTITUTION: An external use pharmaceutical composition for preventing and treating inflammatory diseases contains 0.1-50 wt% of a Carthamus tinctorius seed extract as an active ingredient. The pharmaceutical composition is manufactured in the form of a cream, a gel, a patch, a spray, a liniment, a lotion, an ointment, a paste, or a cataplasma agent. The extract is prepared using water including purified water, C1-C4 alcohols, or a mixture thereof. A cosmetic composition for preventing and treating inflammatory diseases contains the extract as an active ingredient.COPYRIGHT KIPO 2013본 발명은 홍화자 추출물은 염증반응을 유도하는 리포폴리싸카라이드(LPS)를 처리한 후 면역 반응에 의한 인터루킨((interleukin)-1β, IL-1β, IL-6, IL-8), 종양괴사인자((tumor necrosis factor)-α, TNF-α), NO 저해활성 및 COX-2, iNOS의 생성을 탁월하게 억제하는 효과를 보여 염증성 질환의 치료 및 예방에 피부외용 약학조성물 또는 화장료조성물로서 사용할 수 있다.
