The Trustees of Columbia University in the City of New York
发明人:
Konstantin Petrukhin,Christopher Cioffi,Graham Johnson,Rando Allikmets,Emily Freeman,Ping Chen,Michael Conlon,Lei Zhu
申请号：
US15722760
公开号：
US10072016B2
申请日:
2017.10.02
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides a compound having the structure:whereinR1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3, R4, or R5 are other than H；R6 is H, OH, or halogen； andB is a substituted or unsubstituted heterobicycle,wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other thanor a pharmaceutically acceptable salt thereof.
