THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人:
PETRUKHIN, KONSTANTIN,ALLIKMETS, RANDO,JOHNSON, GRAHAM,CIOFFI, CHRISTOPHER,FREEMAN, EMILY,CHEN, PING,CONLON, MICHAEL,ZHU, LEI
申请号：
CA2947174
公开号：
CA2947174A1
申请日:
2015.04.29
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3, R4, or R5 are other than H； R6 is H, OH, or halogen； and B is a substituted or unsubstituted heterobicycle, wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is C1, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is C1, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than or a pharmaceutically acceptable salt thereof.
