A data transmission method and a base station are provided. The method includes: setting up an RRC connection with a UE, and acquiring an information element for requesting C-SGN registration from a message transmitted by the UE during the setup of the RRC connection; transmitting an initial UE message to a connected C-SGN, wherein the C-SGN registers the UE based on the information element for requesting C-SGN registration contained in the initial UE message; after the UE registers to the C-SGN and data is received from the UE, transmitting the data to the C-SGN which then transmits the data to a destination address. By the method, signaling interaction during data transmission is reduced, which may improve efficiency of data transmission and reduce consumption of radio network resources.