Maleate salts of (E)-N-{4[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
Qinghong Lu,Mannching Sherry Ku,Warren Chew,Gloria Cheal,Anthony F. Hadfield,Mahmoud Mirmehrabi
申请号：
US15463998
公开号：
US10035788B2
申请日:
2017.03.20
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
