OLIVIER PESCHARD,ANNE DOUCET,RICHARD LE ROUX,PHILIPPE MONDON
申请号：
FR1454632
公开号：
FR3021319A1
申请日:
2014.05.22
申请国别(地区):
FR
年份:
2015
代理人:
摘要：
The peptide has the general formula X - Pro * - Pro * - Xaa - Y wherein: Xaa is selected from Leucine (Leu, L), Arginine (Arg, R), Lysine (Lys, K), Alanine (Ala, A), Serine (Ser, S), and Aspartic Acid (Asp, D)； At the N-terminal end of the peptide, X is chosen from H, -CO-R 1 and -SO 2 -R 1； At the C-terminal end of the peptide, Y is chosen from OH, OR 1, NH 2, NHR 1 or NR 1 R 2, R 1 and R 2 being, independently of one another, chosen from an alkyl, aryl, aralkyl and alkylaryl group, alkoxy and aryloxy, which may be linear, branched, cyclic, polycyclic, unsaturated, hydroxylated, carbonylated, phosphorylated and / or sulfurized, said group possibly having in its backbone a heteroatom, in particular O, S and / or N； and • Pro * corresponding to Proline, an analogue or derivative thereof. The peptide is adapted to stimulate the synthesis of the molecules constituting the dermal extracellular matrix, in particular collagen 1 and 4 and elastin. It can be used for a cosmetic treatment including anti-aging, anti-wrinkles and fine lines, to improve the mechanical properties of the skin, firmness / tonicity / elasticity / suppleness, to increase the density and volume of the skin, for an effect restructuring and / or to fight against stretch marks. Le peptide répond à la formule générale X - Pro* - Pro* - Xaa - Y dans laquelle : • Xaa est choisi parmi la Leucine (Leu, L), l'Arginine (Arg, R), Lysine (Lys, K), l'Alanine (Ala, A), la Sérine (Ser, S), et l'Acide Aspartique (Asp, D) ； • en extrémité N terminale du peptide, X est choisi parmi H, -CO-R1 et -SO2-R1 ； • en extrémité C terminale du peptide, Y est choisi parmi OH, OR1, NH2, NHR1 ou NR1 R2, • R1 et R2 étant, indépendamment l'un de l'autre, choisis parmi un groupement alkyle, aryle, aralkyle, alkylaryl, alkoxy et aryloxy, pouvant être linéaire, ramifié, cyclique, polycyclique, insaturé, hydroxylé, carbonylé, phosphorylé et/ou soufré, ledit groupement pouvant posséder dans so
