Aleksandar Filip Radovic-Moreno;Robert S. Langer;Omid C. Farokhzad
发明人:
Omid C. Farokhzad,Aleksandar Filip Radovic-Moreno,Robert S. Langer
申请号：
US12097118
公开号：
US09267937B2
申请日:
2006.12.15
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Screening of a library of particles in vivo and/or in vitro using Polyplex Iterative Combinatorial Optimization (PICO) allows for the design of particles for targeting a specific organ, tissue (e.g., cancer), or cell. Particles may, for example, include different targeting agents (e.g., aptamers or plurality of aptamers) on their surfaces, and the aptamer or aptamers may be evolved to provide better targeting of the particles. Libraries of particles are enriched in characteristics of particles that have been found to migrate to a tissue of interest, be taken up by cells, etc. The process may be repeated to engineer particles of a desired specificity or biological function.
