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Dipeptoid prodrugs and their use
专利权人:
BAYER INTELLECTUAL PROPERTY GMBH
发明人:
LERCHEN, HANS-GEORG,MEIBOM, DANIEL,VAKALOPOULOS, ALEXANDROS,ALBRECHT-KÜPPER, BARBARA,KELDENICH, JÖRG,ZIMMERMANN, KATJA,NELL, PETER,KRENZ, URSULA
申请号:
ES09764200
公开号:
ES2524594T3
申请日:
2009.12.03
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
Compound of formula (I) ** Formula ** in which RPD represents a group of formula ** Formula ** in which it means the point of attachment with the respective O atom, L1 means alkan- (C2-C4) - linear chain diol, L2 means alkanol (C1-C3) -linear chain diol, R1 and R3 are the same or different and independently of one another hydrogen or methyl (alanine), propan-2-yl (valine), propan -1-yl (norvaline), 2-methylopropan-1-yl (leucine), 1-methylopropan-1-yl (isoleucine), butan-1-yl (norleucine), tert-butyl (2-tert-butylglycine), phenyl (2-phenylglycine), benzyl (phenylalanine), p-hydroxybenzyl (tyrosine), indole-3-yl-methyl (tryptophan), imidazol-4-ylmethyl (histidine), hydroxymethyl (serine), 2-hydroxyethyl (homoserine) , 1-hydroxyethyl (threonine), mercaptomethyl (cysteine), methylthiomethyl (s-methylocysteine), 2-mercaptoethyl (homocysteine), 2-methylthioethyl (methionine), carbamoylmethyl (asparagine), 2-carbamoylethyl (glutamine), carboxymethyl acid (aspirin) ) , 2-carboxyethyl (glutamic acid), 4-aminobutan-1-yl (lysine), 4-amino-3-hydroxybutan-1-yl (hydroxylysine), 3-aminopropan-1- yl (ornithine), 2-aminoethyl ( 2,4-diaminobutyric acid), aminomethyl (2,3-diaminopropionic acid), 3- guanidinopropan-1-yl (arginine), 3-ureidopropan-1-yl (citrulline), R2 and R4 independently mean each other hydrogen or methyl, or R1 and R2 or R3 and R4 are respectively linked together and together form with the atom to which they are jointly attached, a 3 to 6 membered saturated carbocycle, R5 means hydrogen or (C1-C4) alkyl,Compuesto de fórmula (I)**Fórmula** en la que RPD representa un grupo de fórmula**Fórmula** en los que significa el punto de unión con el átomo de O respectivo, L1 significa alcan-(C2-C4)-diílo de cadena lineal, L2 significa alcan-(C1-C3)-diílo de cadena lineal, R1 y R3 son iguales o distintos y significan independientemente uno de otro hidrógeno o metilo (alanina), propan-2-ilo (valina), propan-1-ilo (norvalina), 2-metilopropan-1-ilo (leucina), 1-metilopropan-1-ilo (
来源网站:
中国工程科技知识中心
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